After J#, X# and some more abberations, Microsoft is now fiddeling with the idea of Script#. This is a code generation tool for JavaScript – you start with a C# class, run the ssc.exe compiler and get JavaScript from the C# source, instead of IL. He also has some integration with Visual Studio working at this point. The obvious target for Script# is the AJaX world.
I haven’t quite made up my mind if I like this approach or not. It definitively seems intriguing for developers that do not (yet) have a solid understanding of UI-side development.